The S&P 500 ended down on Wednesday after a hotter-than-expected U.S. inflation reading added to worries that the Federal Reserve would not cut interest rates anytime soon, while CVS Health and Gilead Sciences rallied after upbeat quarterly reports.

Nvidia (NVDA.O) and Amazon (AMZN.O) dipped more than 1%, with the two AI computing heavyweights weighing on the S&P 500 (.SPX) .

U.S. consumer prices increased in January by the most in nearly a year and a half, reinforcing the Fed's message that it was in no rush to resume cutting rates.

The surge in prices offered a cautionary note to President Donald Trump's push for tariffs on imported goods, which economists have panned as inflationary.

Interest rate futures now suggest traders see about a 70% chance the Fed will reduce rates by another 25 basis points by the end of 2025, down from about an 80% chance on Tuesday, according to CME Fedwatch.

"The market is digesting that the Fed may not cut at all. That's why the stock market is down, said Jake Dollarhide, CEO of Longbow Asset Management in Tulsa, Oklahoma.

The S&P 500 declined 0.27% to end the session at 6,051.97 points.

The Nasdaq gained 0.03% to 19,649.95 points, while the Dow Jones Industrial Average declined 0.50% to 44,368.56 points.

Of the 11 S&P 500 sector indexes, nine declined, led lower by energy (.SPNY) down 2.69%, followed by a 0.91% loss in real estate (.SPLRCR),.

CVS Health (CVS.N) surged 15% after the healthcare conglomerate beat fourth-quarter profit estimates, hinting at improved performance under new CEO David Joyner.